| Portsmouth FC v Ipswich Town FC 19/10/2021 | View match | |
| Accrington Stanley FC v Portsmouth FC 23/10/2021 | View match | |
| Portsmouth FC v Bolton Wanderers FC 30/10/2021 | View match | |
| Portsmouth FC v Cheltenham Town FC 02/11/2021 | View match | |
| Portsmouth FC v Haringey Borough 06/11/2021 | View match | |
| Portsmouth FC v Crystal Palace (U21`s) 09/11/2021 | View match | |
| Wycombe Wanderers FC v Portsmouth FC 13/11/2021 | View match | |
| Portsmouth FC v AFC Wimbledon FC 20/11/2021 | View match | |
| Lincoln City FC v Portsmouth FC 23/11/2021 | View match | |
| Gillingham FC v Portsmouth FC 27/11/2021 | £7.50 | |
| Portsmouth FC v Harrogate Town 04/12/2021 | View match | |
| Portsmouth FC v Sheffield Wednesday FC 07/12/2021 | £7.50 |