| AFC Wimbledon FC v Portsmouth FC 18/01/2022 | £7.50 | |
| Sunderland FC v Portsmouth FC 22/01/2022 | View match | |
| Portsmouth FC v Charlton Athletic FC 31/01/2022 | £7.50 | |
| Oxford United FC v Portsmouth FC 05/02/2022 | View match | |
| Portsmouth FC v Burton Albion FC 08/02/2022 | View match | |
| Portsmouth FC v Doncaster Rovers FC 12/02/2022 | View match | |
| Shrewsbury Town FC v Portsmouth FC 22/02/2022 | View match | |
| Portsmouth FC v Fleetwood Town FC 26/02/2022 | View match | |
| Portsmouth FC v Oxford United FC 01/03/2022 | View match | |
| Portsmouth FC v Accrington Stanley FC 05/03/2022 | View match | |
| Crewe Alexandra FC v Portsmouth FC 08/03/2022 | View match | |
| Ipswich Town FC v Portsmouth FC 12/03/2022 | View match |