| Lewes v Leatherhead 12/10/2021 | View match | |
| Worthing FC v Lewes 23/10/2021 | View match | |
| Lewes v Carshalton Athletic 02/11/2021 | View match | |
| Bishops Stortford v Lewes 06/11/2021 | View match | |
| East Thurrock United v Lewes 09/11/2021 | View match | |
| Lewes v Haringey Borough 13/11/2021 | View match | |
| Lewes v Folkestone Invicta 20/11/2021 | View match | |
| Lewes v Corinthians Casuals 23/11/2021 | View match | |
| Wingate & Finchley FC v Lewes 27/11/2021 | View match | |
| Lewes v Potters Bar Town 04/12/2021 | View match | |
| Bowers & Pitsea v Lewes 11/12/2021 | View match | |
| Horsham v Lewes 27/12/2021 | View match |