| Lewes v Bognor Regis Town 01/01/2022 | View match | |
| Kingstonian FC v Lewes 03/01/2022 | View match | |
| Enfield v Lewes 08/01/2022 | View match | |
| Lewes v Merstham 15/01/2022 | View match | |
| Lewes v Brightlingsea Regent 22/01/2022 | View match | |
| Lewes v Cray Wanderers 25/01/2022 | View match | |
| AFC Hornchurch v Lewes 29/01/2022 | View match | |
| Lewes v East Thurrock United 05/02/2022 | View match | |
| Carshalton Athletic v Lewes 12/02/2022 | View match | |
| Corinthians Casuals v Lewes 26/02/2022 | View match | |
| Lewes v Worthing FC 05/03/2022 | View match | |
| Leatherhead v Lewes 08/03/2022 | View match |