| Witton Albion v Matlock Town 15/01/2022 | View match | |
| Matlock Town v Scarborough Athletic 18/01/2022 | View match | |
| Matlock Town v Bamber Bridge 22/01/2022 | View match | |
| Matlock Town v Lancaster City 05/02/2022 | View match | |
| Matlock Town v Grantham Town 08/02/2022 | View match | |
| Whitby Town v Matlock Town 12/02/2022 | View match | |
| South Shields AFC v Matlock Town 22/02/2022 | View match | |
| FC United Of Manchester v Matlock Town 26/02/2022 | View match | |
| Gainsborough v Matlock Town 05/03/2022 | View match | |
| Matlock Town v Ashton United 08/03/2022 | View match | |
| Matlock Town v Atherton Collieries 12/03/2022 | View match | |
| Mickleover Sports v Matlock Town 19/03/2022 | View match |