| Plymouth Argyle FC v Doncaster Rovers FC 25/09/2021 | £7.50 | |
| Plymouth Argyle FC v Crewe Alexandra FC 28/09/2021 | £7.50 | |
| Lincoln City FC v Plymouth Argyle FC 02/10/2021 | £7.50 | |
| Plymouth Argyle FC v Burton Albion FC 09/10/2021 | £7.50 | |
| Oxford United FC v Plymouth Argyle FC 16/10/2021 | £8.50 | |
| Morecambe FC v Plymouth Argyle FC 23/10/2021 | £7.50 | |
| Sheffield Wednesday FC v Plymouth Argyle FC 07/11/2021 | £10.50 | |
| Plymouth Argyle FC v Wycombe Wanderers FC 23/11/2021 | £7.50 | |
| Plymouth Argyle FC v Wigan Athletic FC 27/11/2021 | £7.50 | |
| Rochdale FC v Plymouth Argyle FC 05/12/2021 | £7.50 | |
| Sunderland FC v Plymouth Argyle FC 11/12/2021 | £7.50 | |
| Plymouth Argyle FC v Charlton Athletic FC 18/12/2021 | £7.50 |