| The Wednesday v Port Vale FC 22/01/1921 | View match | |
| Bury FC v Port Vale FC 29/01/1921 | View match | |
| Port Vale FC v Bury FC 05/02/1921 | View match | |
| Port Vale FC v Notts County FC 12/02/1921 | View match | |
| Port Vale FC v Blackpool FC 26/02/1921 | View match | |
| Blackpool FC v Port Vale FC 05/03/1921 | View match | |
| Port Vale FC v Leicester City FC 12/03/1921 | View match | |
| Leicester City FC v Port Vale FC 19/03/1921 | View match | |
| Port Vale FC v Barnsley FC 25/03/1921 | View match | |
| Cardiff City FC v Port Vale FC 26/03/1921 | View match | |
| Barnsley FC v Port Vale FC 28/03/1921 | View match | |
| Port Vale FC v Cardiff City FC 02/04/1921 | View match |