| Motherwell FC v Renton 05/02/1921 | View match | |
| Rangers (Glasgow) FC v Greenock Morton 05/02/1921 | View match | |
| Vale Of Leven v Celtic (Glasgow) FC 05/02/1921 | View match | |
| Brentford FC v Swansea Town 05/02/1921 | View match | |
| Blackpool FC v Tottenham Hotspur FC 05/02/1921 | View match | |
| Clapton Orient v South Shields AFC 05/02/1921 | View match | |
| Birmingham v Notts County FC 05/02/1921 | View match | |
| Blackpool FC v The Wednesday 05/02/1921 | View match | |
| Cardiff City FC v Stoke 05/02/1921 | View match | |
| Third Lanark v Falkirk FC 05/02/1921 | View match | |
| St Mirren FC v Airdrieonians (Old) 05/02/1921 | View match | |
| Rotherham County v Barnsley FC 05/02/1921 | View match |