| Southampton FC v Leicester City FC 13/12/2017 | £6.50 | |
| Southampton FC v Huddersfield Town FC 23/12/2017 | £6.50 | |
| Tottenham Hotspur FC v Southampton FC 26/12/2017 | £7.50 | |
| Southampton FC v Tottenham Hotspur FC 21/01/2018 | £12.50 | |
| Southampton FC v Brighton & Hove Albion FC 31/01/2018 | £7.00 | |
| Southampton FC v Brighton & Hove Albion FC 31/01/2018 | £6.50 | |
| West Bromwich Albion FC v Southampton FC 03/02/2018 | £6.50 | |
| Leicester City FC v Southampton FC 19/04/2018 | £6.50 | |
| Chelsea FC v Southampton FC 22/04/2018 | £7.00 | |
| Brighton & Hove Albion FC v Southampton FC 28/08/2018 | £8.50 | |
| Crystal Palace FC v Southampton FC 01/09/2018 | £6.50 | |
| Southampton FC v Brighton & Hove Albion FC 17/09/2018 | £6.50 |