| Southampton FC v West Ham United FC 02/03/2022 | £7.50 | |
| Southampton FC v Newcastle United FC 10/03/2022 | £7.50 | |
| Southampton FC v Manchester City FC 20/03/2022 | £7.50 | |
| Leeds United FC v Southampton FC 02/04/2022 | £7.50 | |
| Southampton FC v Chelsea FC 09/04/2022 | £7.50 | |
| Southampton FC v Arsenal FC 16/04/2022 | £7.50 | |
| Southampton FC v Liverpool FC 17/05/2022 | £8.50 | |
| Leicester City FC v Southampton FC 22/05/2022 | £7.50 | |
| Tottenham Hotspur FC v Southampton FC 06/08/2022 | £8.00 | |
| Tottenham Hotspur FC v Southampton FC 06/08/2022 | £7.00 | |
| Southampton FC v Leeds United FC 13/08/2022 | £8.00 | |
| Cambridge United FC v Southampton FC 23/08/2022 | £8.00 |