| Brentford FC v West Ham United FC 31/07/2021 | £7.50 | |
| Southampton FC v West Ham United FC 11/09/2021 | £7.50 | |
| West Ham United FC v Manchester United FC 19/09/2021 | £7.50 | |
| Manchester United FC v West Ham United FC 22/09/2021 | £5.99 | |
| Leeds United FC v West Ham United FC 25/09/2021 | £7.50 | |
| Everton FC v West Ham United FC 17/10/2021 | £7.50 | |
| West Ham United FC v Racing Genk 21/10/2021 | £7.50 | |
| West Ham United FC v Manchester City FC 27/10/2021 | £7.50 | |
| West Ham United FC v Liverpool FC 07/11/2021 | £7.50 | |
| Manchester City FC v West Ham United FC 28/11/2021 | £7.50 | |
| West Ham United FC v Brighton & Hove Albion FC 01/12/2021 | £9.50 | |
| Arsenal FC v West Ham United FC 15/12/2021 | £5.50 |