| Guiseley AFC v Marine 13/08/2022 | View match | |
| Morpeth Town A.F.C. v Guiseley AFC 16/08/2022 | View match | |
| Nantwich Town v Guiseley AFC 20/08/2022 | View match | |
| Guiseley AFC v Whitby Town 23/08/2022 | View match | |
| Stalybridge v Guiseley AFC 27/08/2022 | View match | |
| Guiseley AFC v Bamber Bridge 29/08/2022 | View match | |
| South Shields AFC v Guiseley AFC 06/09/2022 | View match | |
| Guiseley AFC v Marske United 13/09/2022 | View match | |
| Guiseley AFC v Matlock Town 20/09/2022 | View match | |
| Hyde United v Guiseley AFC 24/09/2022 | View match | |
| Gainsborough v Guiseley AFC 27/09/2022 | View match | |
| Guiseley AFC v Warrington Rylands FC 01/10/2022 | View match |