| Luton Town FC v Harrogate Town 09/01/2022 | £7.50 | |
| Luton Town FC v AFC Bournemouth 15/01/2022 | £7.50 | |
| Luton Town FC v Blackburn Rovers FC 29/01/2022 | £7.50 | |
| Swansea City FC v Luton Town FC 01/02/2022 | £8.50 | |
| Cambridge United FC v Luton Town FC 05/02/2022 | £7.50 | |
| Luton Town FC v Barnsley FC 08/02/2022 | £7.50 | |
| Luton Town FC v Derby County FC 26/02/2022 | £7.50 | |
| Luton Town FC v Chelsea FC 02/03/2022 | £8.50 | |
| Coventry City FC v Luton Town FC 08/03/2022 | £7.50 | |
| Luton Town FC v Queens Park Rangers FC 13/03/2022 | £7.50 | |
| Hull City FC v Luton Town FC 19/03/2022 | £7.50 | |
| Luton Town FC v Millwall FC 02/04/2022 | £7.50 |