| Swansea City FC v Luton Town FC 01/02/2022 | £8.50 | |
| Cambridge United FC v Luton Town FC 05/02/2022 | £7.50 | |
| Luton Town FC v Barnsley FC 08/02/2022 | £7.50 | |
| Luton Town FC v Derby County FC 26/02/2022 | £7.50 | |
| Luton Town FC v Chelsea FC 02/03/2022 | £8.50 | |
| Coventry City FC v Luton Town FC 08/03/2022 | £7.50 | |
| Luton Town FC v Queens Park Rangers FC 13/03/2022 | £7.50 | |
| Hull City FC v Luton Town FC 19/03/2022 | £7.50 | |
| Luton Town FC v Millwall FC 02/04/2022 | £7.50 | |
| Peterborough United FC v Luton Town FC 05/04/2022 | £7.50 | |
| Huddersfield Town FC v Luton Town FC 11/04/2022 | £7.50 | |
| Cardiff City FC v Luton Town FC 18/04/2022 | £8.00 |