| Orient v Oldham Athletic FC 10/01/1981 | View match | |
| Orient v Cardiff City FC 17/01/1981 | View match | |
| Blackburn Rovers FC v Orient 31/01/1981 | View match | |
| Orient v Wrexham FC 07/02/1981 | View match | |
| Grimsby Town FC v Orient 14/02/1981 | View match | |
| Derby County FC v Orient 21/02/1981 | View match | |
| Orient v Luton Town FC 01/03/1981 | View match | |
| Preston North End FC v Orient 07/03/1981 | View match | |
| Orient v Arsenal FC 17/03/1981 | £6.99 | |
| Notts County FC v Orient 21/03/1981 | View match | |
| Orient v Sheffield Wednesday FC 28/03/1981 | View match | |
| Orient v Queens Park Rangers FC 31/03/1981 | View match |