| Everton FC v Brentford FC 05/02/2022 | £7.50 | |
| Huddersfield Town FC v Barnsley FC 05/02/2022 | £7.50 | |
| Kidderminister Harriers v West Ham United FC 05/02/2022 | £8.50 | |
| Manchester City FC v Fulham FC 05/02/2022 | £7.50 | |
| Peterborough United FC v Queens Park Rangers FC 05/02/2022 | £6.50 | |
| Southampton FC v Coventry City FC 05/02/2022 | £7.50 | |
| Tottenham Hotspur FC v Brighton & Hove Albion FC 05/02/2022 | £8.00 | |
| Rochdale FC v Carlisle United FC 05/02/2022 | £7.50 | |
| Swansea City FC v Blackburn Rovers FC 05/02/2022 | £8.50 | |
| Barrow AFC v Tranmere Rovers FC 05/02/2022 | £12.50 | |
| Swindon Town FC v Exeter City FC 05/02/2022 | £7.50 | |
| Burton Albion FC v Sheffield Wednesday FC 05/02/2022 | £9.50 |