| Southampton FC v Crystal Palace FC 25/01/2006 | View match | |
| Leicester City FC v Southampton FC 28/01/2006 | £4.80 | |
| Plymouth Argyle FC v Southampton FC 31/01/2006 | View match | |
| Southampton FC v Derby County FC 04/02/2006 | View match | |
| Reading FC v Southampton FC 10/02/2006 | View match | |
| Southampton FC v Preston North End FC 15/02/2006 | £4.50 | |
| Southampton FC v Preston North End FC 15/02/2006 | £4.00 | |
| Southampton FC v Preston North End FC 15/02/2006 | £4.50 | |
| Newcastle United FC v Southampton FC 18/02/2006 | £4.90 | |
| Southampton FC v Sheffield Wednesday FC 25/02/2006 | £3.00 | |
| Southampton FC v Coventry City FC 04/03/2006 | View match | |
| Crewe Alexandra FC v Southampton FC 11/03/2006 | View match |