| Southampton FC v Arsenal FC 16/04/2022 | £7.50 | |
| Burnley FC v Southampton FC 21/04/2022 | View match | |
| Brighton & Hove Albion FC v Southampton FC 24/04/2022 | View match | |
| Southampton FC v Crystal Palace FC 30/04/2022 | View match | |
| Brentford FC v Southampton FC 07/05/2022 | View match | |
| Southampton FC v Liverpool FC 17/05/2022 | £8.50 | |
| Leicester City FC v Southampton FC 22/05/2022 | £7.50 | |
| Watford FC v Southampton FC 23/07/2022 | View match | |
| Tottenham Hotspur FC v Southampton FC 06/08/2022 | £8.00 | |
| Tottenham Hotspur FC v Southampton FC 06/08/2022 | £7.00 | |
| Southampton FC v Leeds United FC 13/08/2022 | £8.00 | |
| Leicester City FC v Southampton FC 20/08/2022 | View match |