| Southampton FC v Burnley FC 23/10/2021 | £7.50 | |
| Chelsea FC v Southampton FC 26/10/2021 | £7.50 | |
| Watford FC v Southampton FC 30/10/2021 | View match | |
| Southampton FC v Aston Villa FC 05/11/2021 | £7.50 | |
| Norwich City FC v Southampton FC 20/11/2021 | View match | |
| Liverpool FC v Southampton FC 27/11/2021 | View match | |
| Southampton FC v Leicester City FC 01/12/2021 | View match | |
| Southampton FC v Brighton & Hove Albion FC 04/12/2021 | £7.50 | |
| Arsenal FC v Southampton FC 11/12/2021 | £7.50 | |
| Crystal Palace FC v Southampton FC 15/12/2021 | £7.50 | |
| West Ham United FC v Southampton FC 26/12/2021 | View match | |
| Southampton FC v Tottenham Hotspur FC 28/12/2021 | £7.50 |