| Southampton FC v Swansea Town 14/01/1950 | View match | |
| Leeds United FC v Southampton FC 21/01/1950 | View match | |
| Southampton FC v Torquay United FC 28/01/1950 | View match | |
| Southampton FC v Bury FC 04/02/1950 | View match | |
| Sheffield United FC v Southampton FC 11/02/1950 | View match | |
| Southampton FC v Coventry City FC 18/02/1950 | View match | |
| Tottenham Hotspur FC v Southampton FC 25/02/1950 | View match | |
| Southampton FC v Cardiff City FC 04/03/1950 | View match | |
| Blackburn Rovers FC v Southampton FC 11/03/1950 | View match | |
| Southampton FC v Brentford FC 18/03/1950 | £25.00 | |
| Hull City FC v Southampton FC 25/03/1950 | View match | |
| Southampton FC v Chesterfield FC 01/04/1950 | £20.00 |