| Bradford Park Avenue v Southampton FC 08/04/1950 | View match | |
| Southampton FC v Sheffield United FC 10/04/1950 | £20.00 | |
| Southampton FC v Sheffield Wednesday FC 15/04/1950 | £20.00 | |
| Cardiff City FC v Southampton FC 17/04/1950 | View match | |
| Plymouth Argyle FC v Southampton FC 22/04/1950 | View match | |
| Southampton FC v Leicester City FC 29/04/1950 | View match | |
| Southampton FC v West Ham United FC 06/05/1950 | View match | |
| Barnsley FC v Southampton FC 19/08/1950 | View match | |
| Southampton FC v Doncaster Rovers FC 23/08/1950 | View match | |
| Southampton FC v Sheffield United FC 26/08/1950 | View match | |
| Doncaster Rovers FC v Southampton FC 30/08/1950 | View match | |
| Luton Town FC v Southampton FC 02/09/1950 | View match |