| Southampton FC v Plymouth Argyle FC 07/08/2010 | £5.50 | |
| Southampton FC v AFC Bournemouth 10/08/2010 | £5.50 | |
| Southampton FC v Bolton Wanderers FC 24/08/2010 | £5.50 | |
| Southampton FC v Rochdale FC 04/09/2010 | £5.50 | |
| Southampton FC v Colchester United FC 18/09/2010 | £5.50 | |
| Sheffield Wednesday FC v Southampton FC 25/09/2010 | £4.50 | |
| Southampton FC v Tranmere Rovers FC 09/10/2010 | £5.50 | |
| Southampton FC v Oldham Athletic FC 23/10/2010 | £5.50 | |
| Southampton FC v Shrewsbury Town FC 06/11/2010 | £5.50 | |
| Southampton FC v Brighton & Hove Albion FC 23/11/2010 | £6.50 | |
| Southampton FC v Brighton & Hove Albion FC 23/11/2010 | £4.00 | |
| Southampton FC v Brighton & Hove Albion FC 23/11/2010 | £4.00 |