| Southampton FC v Colchester United FC 18/09/2010 | £5.50 | |
| Sheffield Wednesday FC v Southampton FC 25/09/2010 | £4.50 | |
| Southampton FC v Tranmere Rovers FC 09/10/2010 | £5.50 | |
| Southampton FC v Oldham Athletic FC 23/10/2010 | £5.50 | |
| Southampton FC v Shrewsbury Town FC 06/11/2010 | £5.50 | |
| Southampton FC v Brighton & Hove Albion FC 23/11/2010 | £6.50 | |
| Southampton FC v Brighton & Hove Albion FC 23/11/2010 | £4.00 | |
| Southampton FC v Brighton & Hove Albion FC 23/11/2010 | £4.00 | |
| Southampton FC v Brentford FC 11/12/2010 | £5.50 | |
| Southampton FC v Exeter City FC 01/01/2011 | £5.00 | |
| Southampton FC v Exeter City FC 01/01/2011 | £5.50 | |
| Southampton FC v Notts County FC 15/01/2011 | £5.50 |