| Aston Villa FC v Burnley FC 18/12/2021 | £8.50 | |
| Sheffield Wednesday FC v Accrington Stanley FC 18/12/2021 | £7.50 | |
| AFC Wimbledon FC v Portsmouth FC 18/12/2021 | £7.50 | |
| Leeds United FC v Arsenal FC 18/12/2021 | £7.50 | |
| Newcastle United FC v Manchester City FC 19/12/2021 | £9.50 | |
| Wolverhampton Wanderers FC v Chelsea FC 19/12/2021 | £7.50 | |
| Arsenal FC v Sunderland FC 21/12/2021 | £7.50 | |
| Brentford FC v Chelsea FC 22/12/2021 | £7.50 | |
| Tottenham Hotspur FC v West Ham United FC 22/12/2021 | £5.99 | |
| Liverpool FC v Leicester City FC 22/12/2021 | £11.99 | |
| Millwall FC v Swansea City FC 26/12/2021 | £7.50 | |
| Tranmere Rovers FC v Barrow AFC 26/12/2021 | £7.50 |