| Everton FC v Liverpool FC 01/12/2021 | £7.50 | |
| West Ham United FC v Brighton & Hove Albion FC 01/12/2021 | £9.50 | |
| Wolverhampton Wanderers FC v Burnley FC 01/12/2021 | £7.50 | |
| Sheffield Wednesday FC v Hartlepool United 01/12/2021 | £7.50 | |
| Manchester United FC v Arsenal FC 02/12/2021 | £8.50 | |
| Southampton FC v Brighton & Hove Albion FC 04/12/2021 | £7.50 | |
| Southampton FC v Brighton & Hove Albion FC 04/12/2021 | £6.00 | |
| Wolverhampton Wanderers FC v Liverpool FC 04/12/2021 | £7.50 | |
| AFC Wimbledon FC v Cheltenham Town FC 04/12/2021 | £7.50 | |
| Cardiff City FC v Sheffield United FC 04/12/2021 | £7.00 | |
| Coventry City FC v West Bromwich Albion FC 04/12/2021 | £7.50 | |
| Rochdale FC v Plymouth Argyle FC 05/12/2021 | £7.50 |