| Millwall FC v Derby County FC 06/11/2021 | £7.50 | |
| AFC Wimbledon FC v Guiseley AFC 06/11/2021 | £7.50 | |
| Carlisle United FC v Horsham 06/11/2021 | £9.50 | |
| Sheffield Wednesday FC v Plymouth Argyle FC 07/11/2021 | £10.50 | |
| Rochdale FC v Notts County FC 07/11/2021 | £7.50 | |
| Everton FC v Tottenham Hotspur FC 07/11/2021 | £7.50 | |
| Leeds United FC v Leicester City FC 07/11/2021 | £7.50 | |
| West Ham United FC v Liverpool FC 07/11/2021 | £7.50 | |
| Arsenal FC v Watford FC 07/11/2021 | £7.50 | |
| Arsenal FC v Watford FC 07/11/2021 | £5.50 | |
| Sheffield Wednesday FC v Harrogate Town 09/11/2021 | £7.50 | |
| Rochdale FC v Bolton Wanderers FC 09/11/2021 | £7.50 |