| Peterborough United FC v Middlesbrough FC 02/04/2022 | £7.50 | |
| Barrow AFC v Port Vale FC 02/04/2022 | £7.50 | |
| Newport County AFC v Exeter City FC 02/04/2022 | £8.50 | |
| Rochdale FC v Swindon Town FC 02/04/2022 | £7.50 | |
| Walsall FC v Leyton Orient FC 02/04/2022 | £7.50 | |
| Burnley FC v Manchester City FC 02/04/2022 | £9.50 | |
| Chelsea FC v Brentford FC 02/04/2022 | £8.50 | |
| Sheffield Wednesday FC v AFC Wimbledon FC 02/04/2022 | £7.50 | |
| Leeds United FC v Southampton FC 02/04/2022 | £7.50 | |
| Liverpool FC v Watford FC 02/04/2022 | £7.50 | |
| West Ham United FC v Everton FC 03/04/2022 | £7.50 | |
| Birmingham City FC v West Bromwich Albion FC 03/04/2022 | £7.50 |