| Crystal Palace FC v Arsenal FC 04/04/2022 | £7.50 | |
| Peterborough United FC v Luton Town FC 05/04/2022 | £7.50 | |
| Preston North End FC v Blackpool FC 05/04/2022 | £7.50 | |
| AFC Wimbledon FC v Charlton Athletic FC 05/04/2022 | £7.50 | |
| Leicester City FC v PSV Eindhoven 07/04/2022 | £7.50 | |
| Millwall FC v Barnsley FC 09/04/2022 | £7.50 | |
| Swansea City FC v Derby County FC 09/04/2022 | £8.50 | |
| Carlisle United FC v Exeter City FC 09/04/2022 | £7.50 | |
| Northampton Town FC v Bradford City FC 09/04/2022 | £7.50 | |
| Swindon Town FC v Newport County AFC 09/04/2022 | £7.50 | |
| Southampton FC v Chelsea FC 09/04/2022 | £7.50 | |
| Arsenal FC v Brighton & Hove Albion FC 09/04/2022 | £7.50 |