| Southampton FC v Bolton Wanderers FC 24/08/2010 | £5.50 | |
| Bristol Rovers FC v Southampton FC 28/08/2010 | View match | |
| Southampton FC v Rochdale FC 04/09/2010 | £5.50 | |
| Swindon Town FC v Southampton FC 11/09/2010 | View match | |
| MK Dons (Milton Keynes Dons) v Southampton FC 15/09/2010 | View match | |
| Southampton FC v Colchester United FC 18/09/2010 | £5.50 | |
| Sheffield Wednesday FC v Southampton FC 25/09/2010 | £4.50 | |
| Yeovil Town FC v Southampton FC 28/09/2010 | View match | |
| Southampton FC v AFC Bournemouth 02/10/2010 | View match | |
| Southampton FC v Tranmere Rovers FC 09/10/2010 | £5.50 | |
| Huddersfield Town FC v Southampton FC 16/10/2010 | View match | |
| Southampton FC v Oldham Athletic FC 23/10/2010 | £5.50 |