| Southampton FC v West Bromwich Albion FC 16/01/2016 | £4.50 | |
| Manchester United FC v Southampton FC 23/01/2016 | £5.50 | |
| Arsenal FC v Southampton FC 02/02/2016 | £6.00 | |
| Arsenal FC v Southampton FC 02/02/2016 | £7.00 | |
| Southampton FC v West Ham United FC 06/02/2016 | View match | |
| Swansea City FC v Southampton FC 13/02/2016 | View match | |
| Southampton FC v Chelsea FC 27/02/2016 | ||
| AFC Bournemouth v Southampton FC 01/03/2016 | £6.00 | |
| Southampton FC v Sunderland FC 05/03/2016 | View match | |
| Stoke City FC v Southampton FC 12/03/2016 | View match | |
| Southampton FC v Liverpool FC 20/03/2016 | £5.50 | |
| Leicester City FC v Southampton FC 03/04/2016 | View match |