| Huddersfield Town FC v Southampton FC 26/08/2017 | View match | |
| Southampton FC v Watford FC 09/09/2017 | View match | |
| Crystal Palace FC v Southampton FC 16/09/2017 | £6.50 | |
| Southampton FC v Manchester United FC 23/09/2017 | £7.50 | |
| Stoke City FC v Southampton FC 30/09/2017 | View match | |
| Southampton FC v Newcastle United FC 15/10/2017 | View match | |
| Southampton FC v West Bromwich Albion FC 21/10/2017 | £6.50 | |
| Brighton & Hove Albion FC v Southampton FC 29/10/2017 | View match | |
| Southampton FC v Burnley FC 04/11/2017 | View match | |
| Liverpool FC v Southampton FC 18/11/2017 | View match | |
| Southampton FC v Everton FC 26/11/2017 | £5.50 | |
| Manchester City FC v Southampton FC 29/11/2017 | £6.50 |