| Liverpool FC v Southampton FC 22/09/2018 | View match | |
| Wolverhampton Wanderers FC v Southampton FC 29/09/2018 | View match | |
| Everton FC v Southampton FC 02/10/2018 | View match | |
| Southampton FC v Chelsea FC 07/10/2018 | £6.50 | |
| AFC Bournemouth v Southampton FC 20/10/2018 | View match | |
| Southampton FC v Newcastle United FC 27/10/2018 | View match | |
| Manchester City FC v Southampton FC 04/11/2018 | £7.50 | |
| Southampton FC v Watford FC 10/11/2018 | View match | |
| Fulham FC v Southampton FC 24/11/2018 | View match | |
| Leicester City FC v Southampton FC 27/11/2018 | View match | |
| Southampton FC v Manchester United FC 01/12/2018 | View match | |
| Tottenham Hotspur FC v Southampton FC 05/12/2018 | £6.50 |