| Crystal Palace FC v Southampton FC 15/12/2021 | £7.50 | |
| West Ham United FC v Southampton FC 26/12/2021 | View match | |
| Southampton FC v Tottenham Hotspur FC 28/12/2021 | £7.50 | |
| Southampton FC v Newcastle United FC 02/01/2022 | View match | |
| Swansea City FC v Southampton FC 08/01/2022 | £8.50 | |
| Southampton FC v Brentford FC 11/01/2022 | View match | |
| Wolverhampton Wanderers FC v Southampton FC 15/01/2022 | View match | |
| Southampton FC v Manchester City FC 22/01/2022 | View match | |
| Southampton FC v Coventry City FC 05/02/2022 | £7.50 | |
| Tottenham Hotspur FC v Southampton FC 09/02/2022 | View match | |
| Manchester United FC v Southampton FC 12/02/2022 | £5.99 | |
| Southampton FC v Everton FC 19/02/2022 | £7.50 |