| Aston Villa FC v Southampton FC 16/09/2022 | View match | |
| Southampton FC v Everton FC 01/10/2022 | View match | |
| Manchester City FC v Southampton FC 08/10/2022 | View match | |
| Southampton FC v West Ham United FC 16/10/2022 | View match | |
| AFC Bournemouth v Southampton FC 19/10/2022 | View match | |
| Southampton FC v Arsenal FC 23/10/2022 | £8.00 | |
| Crystal Palace FC v Southampton FC 29/10/2022 | View match | |
| Southampton FC v Newcastle United FC 06/11/2022 | View match | |
| Southampton FC v Sheffield Wednesday FC 09/11/2022 | View match | |
| Liverpool FC v Southampton FC 12/11/2022 | View match | |
| Southampton FC v Lincoln City FC 20/12/2022 | £8.00 | |
| Southampton FC v Brighton & Hove Albion FC 26/12/2022 | £8.50 |