| Southampton FC v Norwich City FC 25/02/2022 | £8.50 | |
| Southampton FC v West Ham United FC 02/03/2022 | £7.50 | |
| Aston Villa FC v Southampton FC 05/03/2022 | View match | |
| Southampton FC v Newcastle United FC 10/03/2022 | £7.50 | |
| Southampton FC v Watford FC 13/03/2022 | View match | |
| Southampton FC v Manchester City FC 20/03/2022 | £7.50 | |
| Leeds United FC v Southampton FC 02/04/2022 | £7.50 | |
| Southampton FC v Chelsea FC 09/04/2022 | £7.50 | |
| Southampton FC v Arsenal FC 16/04/2022 | £7.50 | |
| Burnley FC v Southampton FC 21/04/2022 | View match | |
| Brighton & Hove Albion FC v Southampton FC 24/04/2022 | View match | |
| Southampton FC v Crystal Palace FC 30/04/2022 | View match |