| York City FC v Southport 24/01/2006 | View match | |
| Southport v Kidderminister Harriers 28/01/2006 | View match | |
| Southport v Canvey Island 11/02/2006 | View match | |
| Cambridge United FC v Southport 18/02/2006 | View match | |
| Exeter City FC v Southport 04/03/2006 | View match | |
| Forest Green Rovers v Southport 11/03/2006 | View match | |
| Southport v Hereford United 14/03/2006 | View match | |
| Southport v Altrincham 18/03/2006 | View match | |
| Southport v Accrington Stanley FC 21/03/2006 | View match | |
| Tamworth v Southport 25/03/2006 | View match | |
| Southport v Crawley Town FC 01/04/2006 | View match | |
| FC Halifax Town v Southport 08/04/2006 | View match |