| Newport County AFC v Leyton Orient FC 20/03/2021 | £7.50 | |
| Carlisle United FC v Leyton Orient FC 23/03/2021 | View match | |
| Leyton Orient FC v Oldham Athletic FC 27/03/2021 | View match | |
| Mansfield Town FC v Leyton Orient FC 02/04/2021 | View match | |
| Leyton Orient FC v Walsall FC 05/04/2021 | View match | |
| Cheltenham Town FC v Leyton Orient FC 10/04/2021 | View match | |
| Harrogate Town v Leyton Orient FC 13/04/2021 | View match | |
| Leyton Orient FC v Barrow AFC 17/04/2021 | View match | |
| Leyton Orient FC v Cambridge United FC 20/04/2021 | View match | |
| Southend United FC v Leyton Orient FC 24/04/2021 | £7.50 | |
| Leyton Orient FC v Carlisle United FC 01/05/2021 | View match | |
| Salford City v Leyton Orient FC 08/05/2021 | £4.99 |