| Forest Green Rovers v Leyton Orient FC 15/03/2022 | View match | |
| Leyton Orient FC v Rochdale FC 19/03/2022 | View match | |
| Harrogate Town v Leyton Orient FC 22/03/2022 | £7.50 | |
| Leyton Orient FC v Barrow AFC 26/03/2022 | View match | |
| Oldham Athletic FC v Leyton Orient FC 29/03/2022 | View match | |
| Walsall FC v Leyton Orient FC 02/04/2022 | £7.50 | |
| Sutton United v Leyton Orient FC 09/04/2022 | View match | |
| Leyton Orient FC v Scunthorpe United FC 15/04/2022 | View match | |
| Swindon Town FC v Leyton Orient FC 18/04/2022 | View match | |
| Leyton Orient FC v Northampton Town FC 23/04/2022 | View match | |
| Crawley Town FC v Leyton Orient FC 30/04/2022 | View match | |
| Leyton Orient FC v Tranmere Rovers FC 07/05/2022 | View match |