| Salford City v Leyton Orient FC 07/08/2021 | £7.50 | |
| Leyton Orient FC v Queens Park Rangers FC 11/08/2021 | £7.50 | |
| Leyton Orient FC v Exeter City FC 14/08/2021 | View match | |
| Carlisle United FC v Leyton Orient FC 21/08/2021 | £7.00 | |
| Leyton Orient FC v Harrogate Town 24/08/2021 | View match | |
| Leyton Orient FC v Bradford City FC 28/08/2021 | View match | |
| Newport County AFC v Leyton Orient FC 04/09/2021 | £7.50 | |
| Leyton Orient FC v Oldham Athletic FC 11/09/2021 | View match | |
| Leyton Orient FC v Southampton (U21`s) 14/09/2021 | View match | |
| Bristol Rovers FC v Leyton Orient FC 18/09/2021 | £7.50 | |
| Leyton Orient FC v Mansfield Town FC 25/09/2021 | View match | |
| Port Vale FC v Leyton Orient FC 02/10/2021 | £7.50 |