| Leyton Orient FC v Salford City 02/01/2021 | View match | |
| Leyton Orient FC v Morecambe FC 16/01/2021 | View match | |
| Leyton Orient FC v Forest Green Rovers 23/01/2021 | View match | |
| Bolton Wanderers FC v Leyton Orient FC 30/01/2021 | View match | |
| Crawley Town FC v Leyton Orient FC 02/02/2021 | View match | |
| Leyton Orient FC v Colchester United FC 06/02/2021 | View match | |
| Leyton Orient FC v Port Vale FC 20/02/2021 | View match | |
| Bradford City FC v Leyton Orient FC 23/02/2021 | £7.50 | |
| Leyton Orient FC v Tranmere Rovers FC 27/02/2021 | View match | |
| Grimsby Town FC v Leyton Orient FC 02/03/2021 | £9.99 | |
| Exeter City FC v Leyton Orient FC 06/03/2021 | View match | |
| Leyton Orient FC v Stevenage Borough FC 09/03/2021 | View match |