| Bristol Rovers FC v Leyton Orient FC 18/09/2021 | £7.50 | |
| Leyton Orient FC v Mansfield Town FC 25/09/2021 | View match | |
| Port Vale FC v Leyton Orient FC 02/10/2021 | £7.50 | |
| Crawley Town FC v Leyton Orient FC 05/10/2021 | View match | |
| Barrow AFC v Leyton Orient FC 09/10/2021 | £8.50 | |
| Leyton Orient FC v Walsall FC 16/10/2021 | View match | |
| Leyton Orient FC v Forest Green Rovers 19/10/2021 | View match | |
| Stevenage Borough FC v Leyton Orient FC 23/10/2021 | £7.50 | |
| Leyton Orient FC v Hartlepool United 30/10/2021 | View match | |
| Leyton Orient FC v Ebbsfleet United 06/11/2021 | View match | |
| Leyton Orient FC v Charlton Athletic FC 09/11/2021 | View match | |
| Rochdale FC v Leyton Orient FC 13/11/2021 | £7.50 |