| Mansfield Town FC v Leyton Orient FC 29/01/2022 | £7.50 | |
| Bradford City FC v Leyton Orient FC 01/02/2022 | View match | |
| Leyton Orient FC v Colchester United FC 05/02/2022 | View match | |
| Exeter City FC v Leyton Orient FC 08/02/2022 | £7.50 | |
| Leyton Orient FC v Salford City 12/02/2022 | View match | |
| Harrogate Town v Leyton Orient FC 19/02/2022 | View match | |
| Leyton Orient FC v Bristol Rovers FC 22/02/2022 | View match | |
| Leyton Orient FC v Carlisle United FC 26/02/2022 | View match | |
| Colchester United FC v Leyton Orient FC 01/03/2022 | View match | |
| Leyton Orient FC v Stevenage Town 05/03/2022 | View match | |
| Leyton Orient FC v Stevenage Borough FC 05/03/2022 | View match | |
| Hartlepool United v Leyton Orient FC 12/03/2022 | £8.50 |