| Leyton Orient FC v Portsmouth FC 19/07/2022 | View match | |
| Leyton Orient FC v Grimsby Town FC 30/07/2022 | View match | |
| Crawley Town FC v Leyton Orient FC 06/08/2022 | £8.00 | |
| Forest Green Rovers v Leyton Orient FC 09/08/2022 | View match | |
| Leyton Orient FC v Mansfield Town FC 13/08/2022 | View match | |
| Swindon Town FC v Leyton Orient FC 16/08/2022 | £8.00 | |
| Colchester United FC v Leyton Orient FC 20/08/2022 | View match | |
| Leyton Orient FC v Hartlepool United 27/08/2022 | View match | |
| Oxford United FC v Leyton Orient FC 30/08/2022 | View match | |
| Leyton Orient FC v Tranmere Rovers FC 03/09/2022 | View match | |
| Rochdale FC v Leyton Orient FC 13/09/2022 | View match | |
| Leyton Orient FC v Walsall FC 17/09/2022 | View match |