| Southampton FC v Manchester United FC 23/09/2017 | £7.50 | |
| Southampton FC v West Bromwich Albion FC 21/10/2017 | £6.50 | |
| Southampton FC v Everton FC 26/11/2017 | £5.50 | |
| Manchester City FC v Southampton FC 29/11/2017 | £5.00 | |
| Manchester City FC v Southampton FC 29/11/2017 | £6.50 | |
| Southampton FC v Leicester City FC 13/12/2017 | £6.50 | |
| Southampton FC v Huddersfield Town FC 23/12/2017 | £6.50 | |
| Tottenham Hotspur FC v Southampton FC 26/12/2017 | £7.50 | |
| Southampton FC v Tottenham Hotspur FC 21/01/2018 | £12.50 | |
| Southampton FC v Brighton & Hove Albion FC 31/01/2018 | £6.50 | |
| West Bromwich Albion FC v Southampton FC 03/02/2018 | £6.50 | |
| Leicester City FC v Southampton FC 19/04/2018 | £6.50 |