| Fulham FC v Southampton FC 26/12/2020 | £7.50 | |
| Southampton FC v Liverpool FC 04/01/2021 | £7.50 | |
| Leicester City FC v Southampton FC 16/01/2021 | £9.99 | |
| Southampton FC v Arsenal FC 26/01/2021 | £7.50 | |
| Manchester United FC v Southampton FC 02/02/2021 | £7.50 | |
| Wolverhampton Wanderers FC v Southampton FC 10/02/2021 | £7.50 | |
| Southampton FC v Wolverhampton Wanderers FC 14/02/2021 | £7.50 | |
| Southampton FC v Chelsea FC 20/02/2021 | £7.50 | |
| Leeds United FC v Southampton FC 23/02/2021 | £7.50 | |
| Everton FC v Southampton FC 01/03/2021 | £7.50 | |
| Manchester City FC v Southampton FC 10/03/2021 | £8.99 | |
| Tottenham Hotspur FC v Southampton FC 21/04/2021 | £8.00 |