| Manchester United FC v Southampton FC 02/02/2021 | £7.50 | |
| Wolverhampton Wanderers FC v Southampton FC 10/02/2021 | £7.50 | |
| Southampton FC v Wolverhampton Wanderers FC 14/02/2021 | £7.50 | |
| Southampton FC v Chelsea FC 20/02/2021 | £7.50 | |
| Leeds United FC v Southampton FC 23/02/2021 | £7.50 | |
| Everton FC v Southampton FC 01/03/2021 | £7.50 | |
| Manchester City FC v Southampton FC 10/03/2021 | £8.99 | |
| Tottenham Hotspur FC v Southampton FC 21/04/2021 | £7.50 | |
| Tottenham Hotspur FC v Southampton FC 21/04/2021 | £8.00 | |
| Southampton FC v Leeds United FC 18/05/2021 | £7.50 | |
| Cardiff City FC v Southampton FC 27/07/2021 | £5.00 | |
| Swansea City FC v Southampton FC 31/07/2021 | £14.99 |