| Southampton FC v West Ham United FC 11/09/2021 | £7.50 | |
| Manchester City FC v Southampton FC 18/09/2021 | £7.50 | |
| Southampton FC v Wolverhampton Wanderers FC 26/09/2021 | £7.50 | |
| Chelsea FC v Southampton FC 02/10/2021 | £5.99 | |
| Southampton FC v Leeds United FC 16/10/2021 | £7.50 | |
| Southampton FC v Burnley FC 23/10/2021 | £7.50 | |
| Chelsea FC v Southampton FC 26/10/2021 | £7.50 | |
| Southampton FC v Aston Villa FC 05/11/2021 | £7.50 | |
| Southampton FC v Brighton & Hove Albion FC 04/12/2021 | £7.50 | |
| Arsenal FC v Southampton FC 11/12/2021 | £7.50 | |
| Crystal Palace FC v Southampton FC 15/12/2021 | £7.50 | |
| Southampton FC v Tottenham Hotspur FC 28/12/2021 | £7.50 |