| Chelsea FC v Southampton FC 22/04/2018 | £7.00 | |
| Crystal Palace FC v Southampton FC 01/09/2018 | £6.50 | |
| Southampton FC v Chelsea FC 07/10/2018 | £6.50 | |
| Manchester City FC v Southampton FC 04/11/2018 | £7.50 | |
| Tottenham Hotspur FC v Southampton FC 05/12/2018 | £7.50 | |
| Tottenham Hotspur FC v Southampton FC 05/12/2018 | £6.50 | |
| Cardiff City FC v Southampton FC 08/12/2018 | £7.00 | |
| Cardiff City FC v Southampton FC 08/12/2018 | £6.50 | |
| Southampton FC v Derby County FC 16/01/2019 | £7.50 | |
| Southampton FC v Everton FC 19/01/2019 | £6.50 | |
| Manchester United FC v Southampton FC 02/03/2019 | £6.50 | |
| Southampton FC v Tottenham Hotspur FC 09/03/2019 | £9.50 |