| Manchester United FC v Southampton FC 13/07/2020 | £7.50 | |
| Southampton FC v Brighton & Hove Albion FC 16/07/2020 | £13.99 | |
| Southampton FC v Sheffield United FC 26/07/2020 | £13.99 | |
| Southampton FC v Tottenham Hotspur FC 20/09/2020 | £7.50 | |
| Southampton FC v Tottenham Hotspur FC 20/09/2020 | £6.50 | |
| Burnley FC v Southampton FC 26/09/2020 | £9.99 | |
| Southampton FC v West Bromwich Albion FC 04/10/2020 | £7.50 | |
| Chelsea FC v Southampton FC 17/10/2020 | £7.50 | |
| Southampton FC v Newcastle United FC 06/11/2020 | £7.50 | |
| Wolverhampton Wanderers FC v Southampton FC 23/11/2020 | £7.50 | |
| Southampton FC v Manchester United FC 29/11/2020 | £7.50 | |
| Southampton FC v Manchester City FC 19/12/2020 | £7.50 |