| Farsley Celtic v Southport 15/10/2022 | View match | |
| Kidderminister Harriers v Southport 22/10/2022 | View match | |
| Spennymoor Town F.C. v Southport 25/10/2022 | View match | |
| Southport v Buxton 29/10/2022 | View match | |
| Southport v Chorley 05/11/2022 | View match | |
| Southport v Brackley Town 08/11/2022 | View match | |
| Southport v Farsley Celtic 12/11/2022 | View match | |
| Southport v Kings Lynn Town 15/11/2022 | View match | |
| Kettering Town v Southport 26/11/2022 | View match | |
| Southport v Scarborough Athletic 03/12/2022 | View match | |
| Curzon Ashton v Southport 26/12/2022 | View match | |
| Southport v Curzon Ashton 02/01/2023 | View match |