| Southport v Blyth Spartans 07/03/2023 | View match | |
| Southport v Boston United 14/03/2023 | View match | |
| Southport v Kettering Town 18/03/2023 | View match | |
| Southport v Alfreton Town 21/03/2023 | View match | |
| Scarborough Athletic v Southport 25/03/2023 | View match | |
| Southport v Gloucester City 01/04/2023 | View match | |
| Southport v Banbury United 04/04/2023 | View match | |
| Bradford Park Avenue v Southport 07/04/2023 | View match | |
| Southport v Chester FC 10/04/2023 | View match | |
| Kings Lynn Town v Southport 15/04/2023 | View match | |
| Southport v Spennymoor Town F.C. 18/04/2023 | View match | |
| Southport v Kidderminister Harriers 22/04/2023 | View match |