| AFC Fylde v Southport 29/08/2022 | View match | |
| Banbury United v Southport 03/09/2022 | View match | |
| Chester FC v Southport 13/09/2022 | View match | |
| Southport v Leamington 24/09/2022 | View match | |
| Southport v Bradford Park Avenue 01/10/2022 | View match | |
| Gloucester City v Southport 08/10/2022 | View match | |
| Farsley Celtic v Southport 15/10/2022 | View match | |
| Kidderminister Harriers v Southport 22/10/2022 | View match | |
| Spennymoor Town F.C. v Southport 25/10/2022 | View match | |
| Southport v Buxton 29/10/2022 | View match | |
| Southport v Chorley 05/11/2022 | View match | |
| Southport v Brackley Town 08/11/2022 | View match |